Cardiff University PhD: biofilm disruption in AMR E. coli
PhD Studentship: The mechanisms of epoxy-tigliane induced biofilm disruption in antibiotic-resistant E. coli.
The Advanced Therapies Group at Cardiff University have a BBSRC/NBIC PhD studentship focused on designing and delivering improvement in the ability to effectively treat multi-drug resistant bacterial biofilms.
Working in close collaboration with Cardiff’s Australian industrial partner, QBiotics this exciting interdisciplinary PhD project will directly address an un-met societal and industrial need i.e. resistance to antimicrobial and anti-biofilm therapies (AMR). The project will work within the Advanced Therapies Group at Cardiff University in an established team of microbiologists, chemists, engineers and clinicians. The studentship will underpin the development of novel therapeutics based upon epoxy-tigliane structures from the Australian rainforest. The results from the study will be used to inform the design and delivery of new synthetic and semi-synthetic structures for the treatment of biofilm-related disease. The student will have the opportunity to spend time working at the QBiotics laboratory in Queensland.
This PhD brings together expertise in the physical (engineering) and biological sciences and, will investigate polymicrobial interactions and biofilm responses to epoxy-tigliane antimicrobial treatment. Using state-of-the-art cell-imaging technologies at Swansea and Cardiff Universities (including confocal laser scanning and atomic force microscopies; CLSM/AFM) this project will study (at a mechanobiological level) the interaction of epoxy-tiglianes with the bacterial cell surface and biofilm extracellular polysaccharide (EPS) matrix. Working at the interface of the engineering and life sciences, the successful student will acquire expertise in biofilm microbiology, biomechanics & in vitro modelling, cell imaging/labelling, and experience in research translation and industrial collaboration.
Project location: Cardiff University School of Dentistry, Heath Park.
Training: At Cardiff in Year 1, the student will obtain mandatory training in cellular microbiology, research ethics and data analysis, as well as enrolling in the NBIC Doctoral Training Centre, which provides interdisciplinary training in biofilm science, engineering and technology.
Stipend/Fees: 4 years funding available for eligible candidates.
Eligibility: UK or (a limited quota of) EU students only, with at least a 2.1 Honours degree (or equivalent) in Biosciences, Microbiology, Biophysics, or Engineering.
Apply: Please submit an up-to-date CV and cover letter with the names of at least two academic referees to Prof. David Thomas at firstname.lastname@example.org.
Apply by: Friday 1 December 2023