Cardiff University Seminar with Rob Kingsley, 3rd June 2021
Salmonella Variants of Interest and Concern.
Salmonella Typhimurium is one of the most common non-typhoidal Salmonella serotypes associated with human, livestock and wild animal infections globally. It is the prototypical Salmonella serotype studied widely in research labs around the world. Its presence in numerous animal species led to the wide held belief that this was a monomorphic broad host range serotype, a contrast to some serotypes that are restricted to one or a small number of hosts. Genomic epidemiology is now revealing a more nuanced picture of this pathogen, where new variants are continually evolving, leading to epidemics with new characteristics that in some cases result in altered pathogenicity and risk to food safety. Insights into the evolution of S. Typhimurium highlights the moving target that Salmonella presents to intervention strategies aimed at excluding it from the food chain, how medical and agriculture practice and policy drives evolution of new variants and presents opportunity to improve risk assessment and guide intervention strategies
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