Research Associate/Fellow – Understanding Bacterial Surface Sensing for Better Biomaterials: Surface Metabolite Analysis

Location: Nottingham
Salary: £26,495 to £38,833 per annum, depending on skills and experience (minimum £29,799 with relevant PhD)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Closes: 21st September 2018
Job Ref: SCI279218

A novel class of polymers developed in our labs show great promise in reducing infections in the clinic. The reason bacteria do not form adherent biofilms on their surface is not well understood so in this Wellcome Trust funded project we aim to elucidate the bacterial surface sensing processes in an interdisciplinary collaboration recruiting both cutting edge analytics and state of the art microbiology. This approach will equip us to design the biomaterials of the future to reduce device centred infections for the post antibiotic era. The work is a continuation of successful collaboration between Morgan Alexander and Paul Williams.

You will be responsible for the development of novel surface chemical analysis to analyse bacterial cell secreted metabolites. Advanced mass spectrometry based analytical approaches will be used to follow surface mediated bacterial signalling at the surface of novel polymers. The techniques available include liquid extraction surface analysis (LESA) coupled to high resolution MS, desorption electrospray ionisation (DESI) and matrix assisted laser desorption/ionisation (MALDI), time of flight secondary ion mass spectrometry (ToF SIMS), and 3DOrbiiSIMS.

A PhD submitted or awarded in Analytical Chemistry using Mass Spectrometry, Surface Chemical Analysis, Chemistry, Biomaterials, Pharmacy, Physics, Engineering, or related discipline is essential.

This is a collaborative project between the School of Pharmacy and the School of Life Sciences.

This full-time post will be offered on a fixed-term contract for a period of 2 years.

We pride ourselves on the collegial and supportive culture created by our staff. We are dedicated to creating an environment which enables both our staff to thrive and achieve their potential. Our commitment to Equality and Diversity has been recognised in the awarding of an Athena SWAN Bronze Award. Applicants wishing to job share will be considered.

Informal enquiries may be addressed to Morgan Alexander or Elizabeth Hudson (email: Morgan.Alexander@nottingham.ac.uk and Elizabeth.Hudson@nottingham.ac.uk). Please note that applications sent directly to these email addresses will not be accepted.

To see more details and apply please see here .