b'Proof of Concept 1AWARDED OCTOBER 2018UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCH COLLABORATOR/SINSTITUTIONManagingBiofilms within distribution pipes present aUniversity ofInternational Paint aquatic biofilmsmajor risk to drinking water safety. In marineSheffield Ltd (AkzoNobel) and via surfaceenvironments, coatings have successfully alteredDr Cymru Welsh manipulation surfaces to mitigate biofilm risks. This projectWater (DCWW)explores the novel application of marine-coatings to drinking water pipes to prevent/limit and manage biofilms by comparing biofilm behaviour using innovative analytical techniques.AcceleratingWe plan to hijack a mechanism used by bacterialUniversity ofBelfry Therapeuticsantisense PMOspathogens to uptake essential nutrients, toNottinghamto the clinic deliver synthetic RNA fragments which can switch off the expression of specific genes required for survival and kill these pathogens in a biofilm. This innovative technology could potentially have a strong impact in combating AMR.A model oralHundreds of microorganisms live in the mouth,University ofUnilever Safety and system for oralmany are harmless while others cause cariesSouthampton Environmentalhealthcare riskand gum disease. This project will utilise anAssurance Centre assessment in vitro model system to investigate how oral(SEAC)hygiene products may affect this complex oral microbiome to better predict product efficacy.PlasmaHeal: coldBiofilms are a major problem in non-healingUniversity of 5D Health Protection plasma to controland infected chronic wounds due to theirLiverpool Group Ltdbiofilms in woundrecalcitrance to immune clearance and dressings andantimicrobial agents. Cold plasma technology is at the wound/ highly effective against biofilm contamination. dressing interface This project will bring together expertise in biofilms, wound care and plasma to develop a novel plasma activated wound dressing.BIOFILMer: aUrological devices are widely used in the clinic toUniversity ofOxford Nanoimaging super-resolutiontreat kidney stones, tumours, and incontinence.Southampton Ltd (ONI) andplatform forThey however suffer from biofilm formation,Center for Biofilm the analysiscausing severe side effects. In this project, we willEngineering (CBE), of crystallineestablish the first platform for super-resolutionMontana State biofilms inanalysis of biofilms in urological devices, enablingUniversityurological devices development of safer and biofilm-resistant treatments.DevelopmentMany microalgal species are grown commerciallyPlymouth MarineVaricon Aquaof a Movingto produce a range of sustainable bioproducts,LaboratoryMembranewith further product diversification hindered Bioreactor (MMBR)by high production costs. This consortia has for the automateddeveloped a membrane based technology to cultivation andcultivate algae as a biofilm, reducing production harvest of algaecosts and opening the possibility to cultivate grown as a biofilm novel high value strains. 46'