b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONTo incorporate a quorumThe general aim of this Proof of Concept of study is toUniversity of5D Health sensing blocker (lactams)develop and evaluate a pioneering wound dressing toLiverpool Protection into wound dressingbe used as a new, smart technology for the effectiveGroup Ltd, platforms to controlmanagement of biofilms in wounds, which has thePenrhos Bio and biofilms potential to greatly enhance patient outcomes andUnileverreduce healthcare costs.Biofilm disruption activityPotential methods to treat wound infections includeUniversity ofIo-Cyte Ltd and of absorbent sustainedusing absorbent dressings containing alginate forNottingham University of action alginate andantimicrobial sustained-release. Alginate-IodineSouthamptoniodine combined woundcombinations have shown considerable promise dressings against single-species biofilms. Here we evaluate disruption of persistent polymicrobial inter-kingdom and single-species wound biofilms utilising different formulations of absorbent sustained-action alginate/iodine dressings in abiotic and biotic biofilm models.Novel hybrid biofilmNutrient removal represents a significant challengeUniversity ofPlantwork technology to removeto the water industry, housing development and localSouthampton Systems Ltdnutrients fromeconomy, particularly in the Solent region. This project wastewater aims to demonstrate a hybrid biofilm system in a full-scale prototype plant achieving total nitrogen and total phosphorus concentrations below 5 and 0.5 mg/L, respectively, in treated effluent. Dry surface biofilms,Surfaces within a healthcare environment can beUniversity ofGenesis understandingcoated with potentially infectious organisms whichHuddersfield Biosciences their formation andsurvive by forming a dry biofilm. The project seeks to development of a testfurther understand the form and function of these model for preventativebiofilms whilst generating a test method to assess surface cleansers preventative surface cleansers.Assessment of the effectBiofilms in water systems used in factories present aUniversity ofUnileverof electrolysed oxidisingproduct spoilage and consumer health risk that mustManchesterwater on biofilm removalbe controlled. Electrolysed oxidizing water (EOW) could from water supplyoffer an alternative to current approaches since it is systems in food andnon-toxic. This project will independently assess EOW refreshments factories for its suitability for implementation by Unilever in production facilities.55'