b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONOrgano-metallicThis study will explore the application of antibiofilmSheffield5D Health HIPIMS-coatednanoscale organo-metallic coatings to advancedHallamProtection antibiofilm advancedwoundcare dressing substrates using the lowUniversity Group Ltdwound dressings environmental impact processes of HIPIMS and aqueous application.This new class of wound dressings would have the potential to greatly enhance patient outcomes and significantly reduce healthcare costs.The standard biofilm: aMethods and materials to support theUniversity ofLGC Ltdreference measurementstandardisation of biofilm analysis which are lackingSouthamptonsystem to supportin all industrial sectors where biofilms are important. routine manipulation,This project aims to address this need by developing innovation andmethods to produce and characterise reference application materials to validate biofilm analysis and technical approaches used in various industrial sectors. Novel approach to treatOsteomyelitis is a bone disease mostly causedUniversity ofCeramisys Ltd osteomyelitis biofilmsby biofilms in bone injuries or surgical sitesNottingham and Upperton combining innovativesometimes leading to bone removal.We will usePharma dual therapy and slowa novel approach to treat osteomyelitis biofilmsSolutionsdrug release combining innovative dual therapy targeting bacterial communication mechanisms with antibiotics and slow drug release.Evaluating theThere is an increasing demand for naturalUniversity ofPukka Herbs Ltdantimicrobial activitysupplements in the consumer healthcare andSouthamptonof herbal infusions:wellbeing market, with more people taking a implications forholistic approach to self-care. Herbal products are consumer healthcarewidely used in traditional medicines. This study and well-being will investigate the antimicrobial effects of Pukka herb products and establish optimal effective combinations. Antibiofilm touch pointThis proposal explores developing plastics on whichUniversity of5D Health plastics microorganisms will not grow, either in planktonicWarwick Protection or biofilm state. The resultant plastics, processableGroup Ltdby typical mass production techniques will enable a huge range of end products across plastics surfaces and touch points.Development of an inThere is a current need for realistic efficacy assaysUniversity ofBear Valley vitro human skin biofilmfor screening hand disinfectant products that areEdinburgh Ventures and model for testing activesimple, affordable and high-throughput. In thisAqualution ingredients for handproject, we will partner with Bear Valley VenturesSystems Limitedhygiene and Aqualution to develop a human skin biofilm model that can be used for high-throughput testing of skin disinfection formulations. To incorporate aThe general aim of this proof of concept study isUniversity ofUnilever and quorum sensingto develop and evaluate a pioneering topical skinGlasgow Penrhos Bioblocker (lactams) intotreatment to be used as a new smart technology topical treatments tofor the effective management of complex biofilm control mixed biofilmsinfections. This has the potential as an alternative on keratinaceousfor anti-microbial resistant infections and reduce infections healthcare costs.57'