b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONNew generationThis project optimises technology to produce intrinsicallyUniversity ofGencoa Ltdcolour-encodedantimicrobial coatings for surgical tools. This addresses anLiverpoolcoatings for surgicalimportant NHS-identified need for self-cleaning surfaces, tools with intrinsiccombined with distinct colour and lustre required for antimicrobial action end-user compliance within surgical theatres. Detailed surface chemistry and biological testing will accelerate commercialisation of existing IP.Measuring biofilmThe placement of catheters into a patients veins isUniversity ofKimal Plcformation in venouswidespread in hospitals, but poses a serious infectionEdinburghcatheters risk due to biofilm formation. We will measure biofilm formation on a range of catheters provided by Kimal Plc, to determine how catheter design can be improved to reduce the risk of biofilm formation.Corneal biofilmBacterial and fungal keratitis is a major problem in manyUniversity ofTecrea Ltd models and low/middle-income countries (LMIC). There is a need forSheffield and Blueberry anti-biofilmstable and affordable treatments that can control diverseTherapeuticsnanoparticles eye infections. Antimicrobial nanoparticle formulations can provide the antimicrobial and physical properties needed to destroy biofilm structures without damage to sensitive eye tissue. Low dose nitric oxideWounds that dont heal are associated with bacteria inUniversity ofSmith+Nephew for the effectivecommunities known as biofilms which are resistant toSouthampton Ltdtreatment of chronicantibiotics. We have shown that low dose nitric oxide wounds can help disperse lung biofilms win patients with cystic fibrosis. This project will test whether nitric oxide can also disperse biofilms from infected wounds.Blue light treatmentListeria monocytogenes is an important foodborneQuadram Chilled Foodof Listeria underpathogen, causing recent fatal outbreaks across EuropeInstitute Associationenvironmentaland South Africa. Listeria can persist in food factories in conditions biofilms despite sanitising procedures. Blue light (~405 nm) could be an additional operator-safe disinfection measure, however its impact against Listeria in factory conditions is unknown.Evaluating anIn the food industry, increased resistance of biofilm- University ofFourth Stateinnovative plasmaforming bacteria such as Listeria has led to a need forSurrey Medicine Ltd(fourth state of matter)new approaches for decontamination of food and technology forfood processing surfaces. This project will evaluate an prevention andinnovative plasma (fourth state of matter) technology management offor biofilm prevention and management on food and biofilms in the foodhard surfaces.industryA novel laboratoryOrganisation of bacteria as communities called biofilmsUniversity ofNeem Biotech biofilm model toin wounds delays healing. In the UK, currently oneSheffield and Welsh Wound accelerate themillion patients live with the physical and emotionalInnovation Centrecommercialisation ofdiscomfort caused by non-healing wounds. This project anti-biofilm productswill help bring to the clinic a unique, revolutionary for the benefit ofcure that will accelerate wound healing by removing patients with chronicbiofilms.woundsFacile fabrication ofTitanium dental implants to replace damaged or missingUniversityOsteoCarea disruptive titaniumteeth can sometimes get infected. We have takenof the West technology usinginspiration from how edible mussels attach to rocks,of England a polydopaminejetties etc. by applying a thin film of the adhesive used by(UWE), Bristolcapturing platform mussels on titanium. The film in turn can hook suitable agents to minimise infection.49'