b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONBioinspired proteinBiofilm formation on indwelling medical devices, suchUniversity ofVirustatictechnology foras ventilators or catheters, contributes significantlyLiverpoolbiofilm prevention onto the chronicity of infections, posing a substantial indwelling medicalhealthcare and economic burden. This project will devices investigate incorporation of natural protein-based technology to indwelling medical devices, and its effectiveness against biofilm formation. AcceleratingWe should design water-treatment biofilms like weNewcastleVeolia Water innovation bydesign Formula 1 racing cars: in a high-performanceUniversity Technologies and designing watercomputer. From models of individual bacteria,Northumbrian treatment biofilmincorporating realistic chemical and mechanicalWater Ltdmedia in silico properties, we will show we can design a new generation of treatment biofilm media in silico. Development ofThis project aims to develop novel biomimeticNewcastleTeleflex Medical novel biomimeticantibiofilm surfaces for catheters without usingUniversity Europe Ltd and surfaces to preventantibiotics or other antimicrobial agents. This wouldUniversity of biofilm formation onaddress catheter associated biofilm infections with theSouthampton catheters aim of improving development of anti-fouling surfaces to prevent biofilm formation in the long-term. Development ofBacterial vaginosis (BV) affects women aged 15-44 yearsUniversity ofVirustatican electrospunbut is difficult to treat during menstruation. This projectBradfordantimicrobialwill engineer a tampon with unique additional layers coated tampon forcontaining a smart antimicrobial protein that is released management ofduring use to manage the bacteria that cause disruption bacterial vaginosis to the normal biofilm of the vagina causing BV.Rapid easy-to-use andA point-of-care wound diagnostic test underLoughboroughSmith+Nephew affordable diagnosticsdevelopment will be validated for rapid quantitativeUniversity Ltd, Birmingham for wound - 2 detection of bacterial load and antimicrobialCity University, sensitivity using clinical isolates of a range of woundLancaster relevant bacterial strains and wound samples.University and Successful validation will be progressed towardsCromerix Ltdfurther optimization and clinical trial supported by an external grant.58'