b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONBiofilm fluorescentThe ability of antibiotics to penetrate the biofilm matrixUniversity ofPerfectus Biomed antibiotics assay is key to their clinical success, but hard to measure. WeWarwick Ltdwill assess a novel method to detect how well antibiotics penetrate biofilms in chronic lung infections. We will use fluorescently-tagged antibiotics within clinically relevant and UKAS accredited biofilm methods.Development ofMarine fouling biofilm contributes to thousands ofUniversity ofInternational Paint synthetic biofilmtonnes excess fuel usage in the shipping industry. WeSouthampton Ltd (AkzoNobel)for calibrating thewill develop a test system that can more accurately effect of coatingspredict how a coating may reduce biofilm viscoelastic on reducing marinedrag to aid in the design and application of better, viscoelastic drag environmentally friendly coatings for marine vessels.QuorumClean This project aims to develop a novel marinePlymouthUnilever R&D Port antifouling technology that outperforms conventionalMarineSunlightapproaches, but with a reduced environmentalLaboratoryimpact. The approach works by disrupting cell-to-cell communication between marine microbes. Potential applications of the technology are diverse and include protection of ship hulls, marine sensors, desalination membranes and aquaculture infrastructure.Advanced testingUnravelling the effects of soiling events and surfaceUniversity ofUnilever R&D platforms to chemistry on bacterial adhesion and biofilm formationLiverpool - Homecare address key over domestic surfaces under realistic environmentalDivisionperformance conditions. Moving away from model surfaces to add variables for hierarchical levels of complexity: surface materials antimicrobial (hard surfaces initially); and biological inputs (single products on bacteria to multi-species colonies and associated soils).domestic surfacesTreatment of zinc- In Steel industry, Basic Oxygen Steelmaking (BOS)NewcastleTata Steel Europecontaminated slurrygenerates significant amount of dust with high Fe contents.Universityin steel production byThe presence of zinc limits Fe recovery as it would cause BioElectrochemicaloperational issues, leading to large amounts of dust Systems being stockpiled. We propose a novel and sustainable BioElectrochemical System (BES) to tackle this challenge.Novel pharmaceuticalAntibiotic-resistant bacteria, particularly within biofilmsUniversity ofDestiny Pharma agents (XF-drugs) toand fungi pose a significant healthcare threat includingSouthampton Plcprevent and proactivelyrespiratory conditions (e.g. Cystic Fibrosis) and chronic manage bacterialwounds such as diabetic foot ulcers (DFU). The purpose biofilm and fungalof this NBIC study is to examine the effectiveness of a infections in dynamicnovel antimicrobial-drug series in two mechanistically model systems distinct and clinically relevant model systems. Development of nextOver 50% of chronic wounds develop localised infectionUniversity ofT-EDTA Ltd, generation synergisticdue to biofilms, impeding wound healing. CurrentLeeds Medipure Ltd antibiofilm treatmentsantimicrobials in wound care have limited effectivenessand 5D Health for wounds against biofilms. The aim is to determine the feasibility ofProtection Group combining new synergistic antimicrobial and antibiofilmLtdagents into one formulation for incorporation into a hydrogel-based low adherent fibrous wound dressing.Influence of phosphatePhosphate is added to drinking water to minimise leadUniversity ofDr Cymru Welsh dosing to preventdissolution from household pipes. However, phosphate,Sheffield Water (DCWW)plumbosolvency oncan favour microbial biofilm formation in drinking water biofilm formationsystems. To optimise the way this chemical is used by in drinking waterwater utilities we need to understand its impact on distribution systems biofilm formation and on water quality and safety.Biofilm evolution inYoghurt production generates wastewater that requiresUniversityBio Loop and Yeo microbial fuel cells fedconsiderable energy to clean. This project will look atof the WestValleyYeo Valley wastewater cleaning dairy waste using bacteria that release electricityof England as a by-product. We will examine which groups of bacteria(UWE), Bristol(biofilms) are best at producing power and where to find them in Yeo Valleys wastewater treatment plant.50'