b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONRapid screeningUrological devices are widely used to treat kidney stones,University ofPublic Health platform fortumours, and incontinence. However, they significantlySouthampton England and shortlisting coatingssuffer from biofilm formation, causing severe side effects.Center for Biofilm against infection Here, we will develop the first microfluidic platform forEngineering (CBE) rapid screening of coatings that prevents/addressesMontana State biofilms, enabling development of safer urological devicesUniversityand with wider potential applications.Advanced biofilmIn this proposal we will develop an innovativeUniversity ofPerlemax Ltdremoval mediated bymultidisciplinary approach to identify key componentsSheffieldtargeted microbubblesof bacterial physicochemical characteristics of both static generated by fluidicand dynamic biofilms, which will provide a biomarker oscillation for biofilm stability and a target for biofilm removal using our patented novel technology of microbubbles generated by fluidic oscillation.Automated in situThis project aims to adopt a uniquely designedNewcastleInternational Paint detection andautomated in situ testing rig to detect and monitorUniversity Ltd (AkzoNobel) monitoring of marinemarine biofilm erosion and study their mechanicaland University of biofilm erosionproperties. This would address the influence ofSouthamptonand mechanicalbiofilms on the drag on marine vessels with the aim properties via customof improving development of anti-fouling coatings to optical coherencereduce fuel costs. tomography (OCT)Validation of the Oxi- Oxi-Tech have developed the ozone producing technologyUniversity ofOxi-TechCell Ozone SystemOxi-Cell to combat bacterial biofilms. Oxi-Cell is fittedSouthampton Solutionsfor the elimination ofin-line to water systems to inhibit microbial growth. To biofilms validate this technology and facilitate the commercial uptake of Oxi-Cell, we will quantify the antimicrobial effects of this system on planktonic and biofilm populations. Plasma for theChronic wounds are costly to treat and significantly affect aUniversity ofFourth State prevention andpatients quality of life. Bacterial biofilms (specific bacterialHull Medicinemanagement ofstructures) play an important role in chronic wounds, and chronic woundare responsible for many antibiotic treatment failures. biofilms This project will test an exciting new technology to remove wound biofilms and promote healing.Development of aThis project will develop a novel non-thermal plasmaUniversityCreo Medical non-thermal plasmaapplicator system for the decontamination of medicalof the WestLtd and Pentax applicator for theendoscopes during re-processing within hospital facilities.of EnglandMedicaldecontamination ofThis addresses the current clinical and economic need to(UWE), Bristolmedical endoscopes ensure that endoscope devices are free from the risk of cross contamination and potential infection for patients.StandardisedBiofilms are rarely found comprised of one single type ofUniversity ofBluTest complex woundmicroorganism, yet the development of new antimicrobialsGlasgow Laboratoriesbiofilm models - atends to focus on testing one bacteria. This project aims robust antimicrobialto develop methods and testing platforms that will allow screening tool industry partners to develop an effective anti-biofilm compounds using a platform representative of wounds.Rapid early andTo feasibility test an optical-fluorescence-basedLoughboroughSmith+Nephew accurate diagnosis detection technique that seeks to quantitatively detectUniversity Ltdof wounds bacterial biofilms in infected wounds against a complex background of normal flora, and determine antibiotic susceptibility. The rapid single-step test, implementable at the bedside, can potentially transform wound care through improved clinical outcome and reduced costs.Commercialisation ofBiofilm formation in burn wounds is associatedUniversity ofPerfectusa burn wound biofilmwith treatment failure, poor clinical outcomes, andBath Biomed Ltdmodel to provide adevelopment of chronic non-healing wounds. This new service for pre- project will develop a UKAS-accredited pre-clinical clinical research andmodel of burn wound infection, that can support testing in academiaboth early-stage and commercial development of new and industry products to control biofilm formation in wounds.53'