b'Proof of Concept 3AWARDED MAY 2020UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONDevelop aComputational biofilm modelling has potential asNewcastleInternational Paint computational toola rapid, low cost route to accelerate ship foulingUniversity Ltd (AkzoNobel) for marine biofilmcontrol coating research & development. This project& University of management aims to develop a unique computational tool toSouthampton predict experimental data on marine biofilm erosion, deformation and drag at mesoscale flow cell as a Proof of Concept.Biofilm productionA membrane-based bioreactor system utilising biofilmPlymouthVaricon Aqua of Phaeodactylumforming microalgae has been developed to solveMarineSolutionstricornutum forthe economic and biological bottlenecks commonlyLaboratoryfucoxanthin associated with conventional microalgal production. This study will establish the economic viability of this novel process using the model marine diatom Phaeodactylum tricornutum for the production of the high-value pigment fucoxanthin.Novel XF drugs in theOral fungal biofilms are common and responsible forCardiff Destiny Pharmatopical managementa significant burden of infection in people. SuccessfulUniversityof Candida albicanstreatment is hindered by biofilm resistance and limited biofilms numbers of effective antifungal drugs. This project will evaluate the novel XF drugs in combatting Candida biofilms and reducing their infection risk using mucosal mouth models.Development ofThe same species of microorganisms colonize skin andUniversity ofPerfectus Biomed molecular support tobehave as pathogens. The biofilm phenotype has beenHuddersfield Ltddetect biofilm causingproposed as a trigger for infection chronicity however pathogens withinorganisms are not routinely screened for this. This chronic infections project aims to identify genetic markers linked to biofilm that can be utilised by clinicians to detect biofilms. Rotating spiral biofilmThis project extends an existing technology based onUniversity ofUnileverreactor for reliablerotating spiral channels to the challenge of harnessingSheffieldengineering andmicrobial biofilms for sustainable production of control of bacterialvaluable chemicals currently uneconomical to communities andsynthesise through alternative routes. The constructed environments forprototype will act as an enabling technology and open use in industrialup new markets for the industrial biotechnology sector.biotechnologyManipulation of gutBiofilm aggregates (diversity, function) influenceUniversity ofSeaweed & Cobiofilms dynamicsnutrients bioavailability from complex food matrices.Glasgowfor enhanced iodineWe will define how gut biofilm aggregates influence bioavailability iodine bioavailability (nutrient of public health interest) from seaweed, an iodine-rich food. Defining how to sustain/engineer these biofilms will enable the industry partners to develop safe evidence-based products.DNA origamiWe aim to fight the bacteria that contribute to gumUniversity ofFrontier IP Group nanostructures as adisease, by creating origami-like DNA nanostructuresCambridge plctool in the disruptionloaded with antibacterial enzymes or proteins. We will of P. gingivalis biofilms optimise the DNA origami to bind specifically to the target bacteria and to improve the penetration and disruption of the biofilms that they form.54'